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They do, however, have the potential for negative effects if taken with other drugs, so let your doctor know if you are taking more than one medication.Doxylamine can be used by itself as a sleep aid or combined with other drugs for cold and allergy relief (usually in a night-time formula).Your access to the NCBI website at gov has been temporarily blocked due to a possible misuse/abuse situation involving your site.This is not an indication of a security issue such as a virus or attack.For people who need to get to sleep, however, the drowsiness is the main benefit of antihistamines.These are usually not prescription drugs and can be purchased at retailers over-the-counter.(There are other types of antihistamines that affect H-2, H-3, and H-4 receptors.) People build up tolerance to them over time and when they stop taking them experience rebound insomnia.Also called histamine antagonists, antihistamines are administered to fight allergic reactions, in which cases sleepiness is considered a possibly undesirable side effect.

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Antihistamines for Hay Fever (Allergic Rhinitis)Newer oral antihistamines, such as Xyzal (levocetirizine), Zyrtec (cetirizine), Allegra (fexofenadine), Clarinex (desloratadine) and Clarinex (loratadine), are very effective therapies for the treatment of hay fever.Older antihistamines, such as diphenhydramine (Benadryl), chlorpheniramine (Chlor-Trimeton), and hydroxyzine (Atarax), also work well but have many side effects.Oral antihistamines work well when taken as-needed, meaning that allergy symptoms improve within an hour or two of taking the medication.Diphenhydramine and doxylamine have anticholinergic properties that make them poor choices for older adults.Recent studies have shown that anticholinergics may increase the risk of dementia.

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